HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis.
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چکیده
منابع مشابه
HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis.
Forty four patients with rheumatoid arthritis (RA) were studied for HLA-DR antigens and for HLA-DQ beta chain gene restriction fragment length polymorphism using DNA hybridisation. A significant increase in the prevalence of the DR4 antigen and a tendency towards an increase of DR1 was found in patients with RA. No allelic form of HLA-DQ restriction fragment length polymorphism patterns was inc...
متن کاملAssociation between HLA-DR antigens and rheumatoid arthritis in Arabs.
Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheum...
متن کاملHLA DR antigens and disease expression in rheumatoid arthritis.
Ninety-four patients with rheumatoid arthritis who possessed one or more of the HLA DR alloantigens 2, 3, or 4 were studied to investigate the genetic influence on disease severity and prognosis. In those with a disease duration of less than 10 years radiological damage was less in patients with DR2 than in those without this antigen. When current joint scores were compared, patients with this ...
متن کاملHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.
The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly and trafficking of HLA-DP molecules have not been studied extensively. However, different HLA-DP variants can be either protective or risk factors for infectious diseases (e.g. he...
متن کاملHLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity.
BACKGROUND Specific alleles present at the HLA-DR/DQ loci seem to be associated with disease activity of rheumatoid arthritis. AIM In the present study, our aim was to investigate the distribution of HLA-DR/DQ alleles among Kurd patients with rheumatoid arthritis and to ascertain their relationship with disease activity. MATERIALS AND METHODS Sixty five patients with rheumatoid arthritis (R...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1990
ISSN: 0003-4967
DOI: 10.1136/ard.49.7.494